AC/UNU Millennium Project
Environmental Pollution and Health Hazards
Resulting From Military Uses of Nanotechnology
Round 2

On behalf of the Millennium Project of the American Council for the United Nations University, we have the honor to invite you to participate in the second round of a two-round Delphi study. The purpose of this study is to identify and rate important forms of nanotechnology-related environmental pollution and health hazards that could result from military activity, and to suggest military research that might reduce or eliminate these problems.

Lux Research estimates that more than $8.6 billion will be spent this year on nanotechnology R&D worldwide, and that 2004 will be the last year that governments outspend corporations in nanotechnology, as activity shifts from basic research to the development of applications. Little is known about the environmental and heath risks of manufactured nanomaterials. The military is a major force in nanotechnology R&D; and hence it can play a key role in understanding and managing nanotechnology risks in general. Your insights are invited to help shape that research agenda.

The enclosed Round 2 shares the results of Round 1 and seeks your views about additional potential environmental pollution and health hazards from future military use of nanotechnology, and research needed to address these risks.

The results will be distributed to relevant military and other research personnel and published in the 2005 State of the Future. Complimentary copies will be sent to those who respond to this questionnaire. No attributions will be made, but respondents will be listed as participants in the report.

The Millennium Project is a global participatory system that collects, synthesizes, and feeds back judgments on an ongoing basis about prospects for the human condition. Its annual State of the Future, Futures Research Methodology, and other special reports are used by decision-makers and educators to add focus to important issues, clarify choices, and improve the quality of decisions. In addition to the Millennium Project sponsors listed below, the Army Environmental Policy Institute is contributing to this study.

Please return your responses by December 25, 2004. You can respond using this on-line version or download the MsWord version from http://www.acunu.org/millennium/nanotech-rd2.doc and e-mail it as an attached file to acunu@igc.org with copies to jglenn@igc.org and tedjgordon@worldnet.att.net.

We look forward to including your views.

Jerome C. Glenn, Director, AC/UNU Millennium Project
Theodore Gordon, Senior Fellow, AC/UNU Millennium Project

Although no attributions will be made, for demographic analysis and so that you can be listed properly as participant in the 2005 State of the Future, and so that a copy can be sent to you, please fill in the information below:

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Introduction
The US National Science Foundation allocated US$30 million in FY 2002 for studies of environmental and health impacts of nanotechnology.  In 2003 the European Union funded the NANOSAFT project to assess the technology's environmental and health risks. Over the next few years, the US EPA is funding several studies on environmental and health impacts of nanotechnology. Other organizations also began researching the facts and implications of advanced nanotechnology. As you address the questions below, please give special attention to research needs beyond these ongoing studies, specifically those that should be conducted by the military.

Your input is welcome on the full range of current and potential future nanotechnologies.

This second round feeds back the results of Round 1, and asks you to:
You need not answer every question; only those about which you have expertise.

Question 1:  Please review the list of potential environmental pollution and health hazards that might result from military uses of nanotechnology in the time periods 2005-2010 and 2010-2025. If there are other important items not listed, please add them in the space provided. Importance is defined as potentially affecting large numbers of people in potentially irreversible ways.

1.1 Potential Use and Potential Impacts between 2005 and 2010

Military Use 2005-2010

Potential Environmental or Health Impact

Nanomaterials in sun screens, camouflage creams, and/or bioweapons skin shields

Absorption of nanoparticles through the skin and/or flushed into the environment and entering the food chain

Nanomaterials (e.g., nanotubes) in uniforms and equipment to make them stronger and lighter

Nanofiber-like materials that break off from uniforms and equipment and enter the body and environment

Nanoparticles in fuel as additives

Inhalation by military staff but also by the population in general

Nanoparticles as surface coverage to make it harder, smoother, stealthy

Erosion of these nanoparticles make them inhalable by military staff but also by the general population

Nanoparticles in weapons such as depleted uranium

Dispersion in the battlefield leads to transport towards cities and villages for further inhalation by the general population, also redispersion from surfaces of the battlefield

Nanoparticles created by the blast of high technology weapons/high temperature combustion processes

Diseases like cancer, lymphoma or leukemia in humans induced by inhalation of nanopollution or ingestion of contaminated food (also animals) See Twin Towers Collapse Phenomenon – inhaled nano-sized pollution

Nanosensors to detect trace concentrations of biochemicals

Absorption of nanoparticles through the skin into the body and environment, concentrating in water and soil, and eventually linking with natural organisms, causing unknown environmental changes

Nanoparticle accelerants and explosives

Accidental dispersal of nanoparticles into the environment

Aging of items with nanostructured surfaces releases nanoparticles that can be inhaled or digested

Nanopollution in the environment and contamination of environment (vegetables, fruits, etc), humans and animals. The contamination can  also infect drinkable water and fish

Radio frequency identification tags to track soldiers and equipment

If implanted in the body could result in materials "leaching" in the body; those in equipment could enter the environment

More effective prophylactics and therapeutics - e.g. time-released polymers that would replace multiple vaccinations

Better control over contracting and spread of illness and disease; however, polymers would end up in the environment

Improved prosthetic devices (non-friction microscopic coatings) and implanted medical devices

Bio-compatibility for these devices and prosthetics has to be established



Please add other military uses of nanotechnology and their environmental or health impact

Military use 2005-2010:
Its environmental or health impact:
Military use 2005-2010:
Its environmental or health impact:
Military use 2005-2010:
Its environmental or health impact:
Military use 2005-2010:
Its environmental or health impact:
Other military uses 2005-2010:
Respectively their environmental or health impact:


1.2 Potential Use and Potential Impacts between 2010-2025

Military Use 2010-2025

Potential Environmental or Health Impacts

Artificial blood cells (respirocytes) dramatically enhance human performance

Cause overheating of the body, bio-breakdowns, and their excretion causes another environmental load

Inorganic, non-biodegradable, nanoparticles for drug release or cancer treatment or "permanent" nanosensors

The non-biodegradable nanoparticles (and perhaps also non-biocompatible) can induce a foreign body reaction, "very particular"

Proteomic targeting, genetically selective "designer quasi-viral components", engineered to select specific human targets based on definable genetic markers.

Organisms mutate, creating "biological-grey-goo" pandemic.

Nanoparticles to "clean-up" contaminated areas

They can create new compounds that can have an impact on the environment

Nanoenhanced WMD

WMD effects

Nanocomputers remove humans from the battlefield

Makes warfighting less costly from the side with the tech and therefore makes warfighting more likely

Ubiquitous surveillance systems are deployed without strong controls on the use of information

Psychological stress from the sense of being watched by strangers

Numerous centimeter-scale buoyant platforms are deployed in the atmosphere

Interference with birds and aircraft, precipitation of damaged devices at uncontrolled locations over Earth's surface

Nanoscale time-release bioweapons for inhalation

Potential pollution of air and waterways; long-term effects on those handling the bodies of victims

Large quantities of smart weapons — especially miniaturized, robotic weapons and intelligent, target-seeking ammunition

Death or serious injury to combatants and to civilians. Extensive, potentially polluting destruction of buildings, roads, and infrastructure

Deliberate high-volume production of nano-built weapons and ammunition

Drain on resources (raw materials and energy supply). Insufficient or undeveloped methods of disposal after need for use has passed

Small receptor-enhancers increase alertness and lower the reaction times of humans (Soldiers)

Leads to addiction and/or subsequent Chronic Fatigue Syndrome, leading to weakness, neural damage and death

Nanaoscale biomolecule-driven motors that enhance the efficiency of ATP (Adenosine Triphosphate) usage, the frequency of generation of ATP and increase the life of ATP molecules in endurance athletes and/or long-haul soldiers

Cause overheating of the body, bio-breakdowns, and possibly lead to Rapid-Onset Muscle Soreness after a stipulated duration, and if allowed to function beyond this duration - may kill the organism thus modified


Please add other military uses of nanotechnology and their environmental or health impact

Military use 2010-2025:

Its environmental or health impact:
Military use 2010-2025:
Its environmental or health impact:
Military use 2010-2025:
Its environmental or health impact:
Military use 2010-2025:
Its environmental or health impact:
Other military uses 2010-2025:
Respectively their environmental or health impact:


Question 2:  Round 1 asked participants to rate a list of research questions, that if pursued might help prevent or reduce environmental and health impacts. The following scale was used to rate the questions:

Potential for gaining new knowledge from the research
5= Will lead to critical knowledge for preventing and/or reducing problems
4= Very likely to lead to critical knowledge for preventing and/or reducing problems
3= May lead to critical knowledge for preventing and/or reducing problems
2= Not likely to lead to critical knowledge for preventing and/or reducing problems
1= A complete waste of time

The tables below present the averages of the ratings in Round 1. Participants were also asked to suggest additional research questions. These new suggestions are listed following the tables. Using the same scale above, please rate the new suggestions.

2.1 Health hazard research questions – Round 1 ratings sorted by Research Potential

2.1.1 How are nanoparticles absorbed into the body through the skin, lungs, eyes, ears, and alimentary canal?

4.46

2.1.2 Once in the body, can nanoparticles evade natural defenses of humans and other animals? What is the likelihood of immune system recognition of nanomaterials?

4.38

2.1.10 What are the surface properties of nanoparticles that alter toxicity? What are the distinct properties of nanoparticles that may alter toxicity?

3.87

2.1.6 How are nanomaterials metabolized and eliminated by the body?

3.73

2.1.5 What are the important unknowns about nanomaterials passing the brain/blood barriers and transversing neural pathways?

3.64

2.1.4 What is unique about the health hazards of manufactured nanomaterials vs. health hazards of particles of a similar size?

3.60

2.1.8 Can nanomaterials concentrate inside humans? If so, in which organs are they most likely to accumulate?

3.53

2.1.9 Can nanoparticles enter egg and sperm cells altering DNA?

3.53

2.1.3 How are they distributed throughout the body?

3.50

2.1.7 What is the nature and quantitative effectiveness of the mechanism for removing nanoparticles from the lungs?

3.50

Please rate the additional heath hazard research questions below using the same scale above.

2.1.11 Develop uniform nomenclature for research and presentation of results.


2.1.12 Do nanoparticles concentrate at critical sites like synapses and tumors?


2.1.13 What are the sizes, aspect ratio, and surface activity determinants of nanoparticle impacts on living organisms (must be studied for specific nanoparticles)?


2.1.14 Effect of exposure to nanoparticles on all lifestages, from fetus to old age, and on all major systems, including neural and immune systems.


2.1.15 Is there built-in auto destruction within the nanoparticles? If so, what happens to the waste materials?


2.1.16 Compared to existing weaponry, how much more deadly will nano-built smart weapons be — especially miniaturized, robotic weapons and intelligent, target-seeking ammunition?


2.1.17 What are potential exposure routes of nanomaterials - both airborne and waterborne?


2.1.18 Are the current toxicity tests used for chemicals appropriate and/or useful for nanomaterials?


2.1.19 How are nanomaterials biotransformed within different species?


2.1.20 Organize data on impacts based on group or class of nanoparticles with respect to chemical composition, size, aspect ratio, and surface activity.


2.1.21 What psychological aspects should be considered?


2.1.22 Investigate regulatory options.


Please suggest other key research questions related to health hazards and/or rephrase those above:


2.2 Environmental Pollution research questions – Round 1 rating sorted by Research Potential

2.2.3 How biodegradable are nanotube-based structures?

4.36

2.2.5 Could nanoparticles enter the food chain by getting into bacteria and protozoa and accumulate there?

4.21

2.2.1 How to identify and dispose of nanomaterial litter?

4.14

2.2.4 How might nanoparticles get into plants and other organisms?

4.14

2.2.2 Do nanoparticles act like bioaccumulants in Nature?

4.07

2.2.7 How can nanotechnology be used for post-battlefield cleanup (including biological, chemical, and nuclear wastes) so that they do not pollute soil and water?

4.00

2.2.6 What are the potential environmental impacts of nanotech water purification systems? [Reformulation suggestion: How to determine whether there are environmental impacts of using functionalized nanomaterials or nanostructured membranes or filters for water purification?]

3.93

2.2.8 What strategies could prevent the “gray goo” problem?

2.79


Please rate the additional environmental pollution research questions/projects below using the same scale above

2.2.9 How do engineered or manufactured nanomaterials behave as compared with natural nanomaterials, or those resulting from combustion processes?


2.2.10 How will nanomaterials enter the environment and will they change when moving from one medium (e.g. air) to another (e.g. water)?


2.2.11 Study current nanoparticle contaminations in post-war fields by high-technology weapons, including smoked cigarette tobacco polluted with depleted uranium.


2.2.12 Are nanoparticles changed in composition, or do they accumulate pollutants in the environment?


2.2.13 How might nanomaterials leach into water tables?


2.2.14 Real inhalation studies (vs. instillation).


2.2.15 Research should be interdisciplinary and international.


2.2.16 Study nanotech impact on ecological systems, and not just on single organisms.


2.2.17 Compared with existing weaponry, how much more damage could nano-built weapons do to buildings, roads, and infrastructure, and how much of a pollution hazard will these create?


2.2.18 What climate change impacts are possible from extremely large-scale operations to provide energy (especially solar) or from mass-produced nano-built weaponry and/or military infrastructure?


2.2.19 What technologies can be used to minimize exposure of nanomaterials?


Please suggest other key research questions related to environmental pollution and/or rephrase those above:


2.3 General questions about addressing environmental and health issues of future nanomaterials – Round 1 Result sorted by Research Potential

2.3.5 What training will be necessary to provide the capacity for oversight for safe development and application of nanotechnology?

4.17

2.3.2 What are the most useful methodologies and protocols for environmental pollution and health hazard studies for the range of nanotechnologies?

4.07

2.3.3 What is a useful classification system to provide a framework to make research judgments and keep track of the state of knowledge about nanotech’s potential pollutions?

4.00

2.3.4 How can toxicologists and pharmaceutical scientists investigating nano particles' ability to evade cell defenses to target disease be best brought together?

4.00

2.3.1 How can standard metrics for nanotech pollution/hazards be developed?

3.86

2.3.8 How can stand-off off-switches be created to deactivate nanotech weapons?

3.18

2.3.6 How can nano-built nanoproducts intensify earlier problems of nanomaterials and create important new ones?

3.00

2.3.7 How can arms-control measures prevent the deployment of powerful nanomanufacturing systems able to produce unprecedented quantities of advanced weapons?

3.00


Please rate the additional general research questions related to environmental pollution or health hazards using the scale above.

2.3.9 Toxicologist and pharmaceutical scientists cannot solve or understand all these nanotech problems acting within just their disciplines. Biomaterialists, immunologists, and embryologists have a better cultural background to understand the physical-chemical and biological interactions of nanoparticles with the human life and environment. A multidisciplinary team is necessary.


2.3.10 Can nanoparticles be made preferentially symbiotic with human hosts, creating a new breed of terrorists?


2.3.11 How can specific research into nano-related environmental pollution and health hazards effectively take into account the fundamental ways that all systems (ecological, economic, political, and social) may be disrupted and transformed by molecular manufacturing on local, national, and global scales?


2.3.12 Establish Nanotech-Environmental summits.


2.3.13 What will be the development timeline for nano-built nanomachines (exponential manufacturing) with military potential? How soon do we have to prepare?


2.3.14 How can energy consumption be minimized and waste/pollution be prevented in the manufacturing of nano/military materials and products? This research would address green manufacturing of nanomaterials--applying green chemistry and green engineering principles.


2.3.15 At what stage in the lifecycle of nano/military materials and products do the major environmental impacts occur (e.g., resource extraction, manufacture, use, end of life)? This research would address life cycle assessment of nanomaterials used in military activities.


2.3.16 What are the commonalities between anthropogenic and manufactured particles?


2.3.17 What are the "representative" nanomaterials that should be used for testing in terms of which nanomaterials may result high exposures?


2.3.18 Are there ways to use novel testing methods, protocols and technologies (e.g. toxicogenomics) to increase the efficiency with which we can generate important risk data for new nanomaterials?


Please suggest other general research questions related to environmental pollution or health hazards and/or rephrase those above::


Question 3:
  Please review the following references to research related to potential environmental and health impacts of military use of nanotechnology. Are there additional major ongoing or planned studies that should be added to the list to help understand the priorities in addressing these questions? If so, please add them in the space provided at the end of the list, and, if possible, provide a sentence or two describing the thrust of the work.

Nanoscience and Nanotechnologies:  Opportunities and Uncertainties. Royal Society and the Royal Academy of Engineering, July 2004 http://www.nanotec.org.uk/finalReport.htm

Overview of Completed and Ongoing Activities in the Field: Safety and Risks of Nanotechnology, Version 2.1, Technologie Management, Switzerland (a survey of surveys.) June 10, 2004. http://www.temas.ch/WWWTEMAS/TEMAS_Homepage.nsf/vwRes/Safety/$FILE/NANOSafety_Version2_1.pdf

Vicki L. Colvin. The Potential Impact of Engineered Nanomaterials, Nature Biotechnology, Nature Publishing Group, (10):1166-70, October 2003

From Genomes to Atoms: The Big Down: Atomtech: Technologies Converging at the Nano Scale, The ETC Group, January 2003. – http://www.etcgroup.org/documents/TheBigDown.pdf

The Nanotech Report 2004, Lux Research, New York 2004
http://www.luxresearchinc.com/tnr2004

Nanotechnology: Small Matter, Many Unknowns, Swiss Reinsurance Company. Zurich, Switzerland, 2004. http://www.swissre.com/INTERNET/pwswpspr.nsf/fmBookMarkFrameSet?ReadForm&BM=../vwAllbyIDKeyLu/ULUR-5YAFFS?OpenDocment

Jürgen Altman and Mark Gubrud, Risks from Military Uses of Nanotechnology. 2002
“Military Uses of Nanotechnology: Perspectives and Concerns”, by Jürgen Altmann, University of Dortmund, Germany, published in SAGE Publications, www.sagepublications,com, Vol. 35(1): 61-79, DOI: 10.1177/0967010604042536 
http://www.ep3.ruhr-uni-bochum.de/bvp/RiskMilNT_Lecce.pdf

Tom McCarthy, World Systems – http://www.mccarthy.cx/WorldSystem/war.htm

Center for Responsible Nanotechnology, The Effects of Molecular Manufacturing on Military and Government Capability and Planning. – http://www.crnano.org/study20.htm

Nanotechnology: Looking As We Leap, Location: Environmental Health Perspectives, 112 (Sept 2004) A741-749. Main Section of EHP Online – http://ehp.niehs.nih.gov/members/2004/112-13/focus.html

Royal Society and The Royal Academy of Engineering, UK, Nanoscience and nanotechnologies opportunities and uncertainties, new report http://www.nanotec.org.uk/finalReport.htm. The report illustrates the fact that nanotechnologies offer many benefits both now and in the future but that public debate is needed about their development. It also highlights the immediate need for research to address uncertainties about the health and environmental effects of nanoparticles – one small area of nanotechnologies. In particular Chapter 5 addresses issues of health effects and nanotoxicology.

Borm, P.J.A., W.G. Kreyling, Toxicological Hazards of Inhaled Nanoparticles—Potential Implications for Drug Delivery, Journal of Nanoscience and Nanotechnology 4(5): 521-531, 2004. This paper gives a brief review on the toxicology of inhaled nanoparticles, including general principles and current paradigms to explain the special case of nanoparticles in pulmonary toxicology.

Donaldson K, Stone V, Tran L.,  Kreyling W.G., Borm P. Nanotoxicology: a new frontier in toxicology. Occup Environ Med 2004;61:727–728

Duncan R., The Dawning Era of Polymer Therapeutics, Nature Reviews, 2: 347-359 (May 2003) http://www.nature.com/reviews/drugdisc. Research at the interface of polymer chemistry and the biomedical sciences has given rise to the first nano-sized (5–100 nm) polymer-based pharmaceuticals, the ‘polymer therapeutics’. Polymer therapeutics includes rationally designed macromolecular drugs, polymer–drug and polymer–protein conjugates, polymeric micelles containing covalently bound drug, and polyplexes for DNA delivery. The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugates, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomics age.

A.M. Gatti , F. Rivasi,  Biocompatibility of micro- and nanoparticles Part I in liver and kidney. Biomaterials June 2002, 23(11):  2381-2387.

A.M. Gatti, Balestri M., Bagni, A. Granulomatosis associated to procelain wear debris, American Journal of Dentistry  2002, 15(6): 369-372.

A.M. Gatti .Biocompatibility of micro- and nano-particles in the colon (part II)  Biomaterials , Feb 2004, 25(3): 385-392

M. Lucarelli, E.Monari, AM. Gatti Boraschi Modulation of defence cell funtion by nanoparticles in vitro. Bioceramics n 16. Ed.M.Barbosa , Ed Treans Tech Publ, (ISBN 0-87849-932-6), Porto 2004, 907-910

Peters, Unger, Gatti, Monari, Kirkpatrick, Effects of nano-scaled particles on endothelial cell function in vitro:Studies on viability, proliferation and inflammation, J. of Material Science: Mat. in Medicine. 2004, 15 (4), 321-325

AM. Gatti, Montanari, Monari, Gambarelli, Capitani, Parisini Detection of micro and nanosized biocompatible particles in blood. J. of Mat. Sci. Mat in Med. 15 (4): 469-472, April 2004

AM. Gatti, Montanari  The so-called Balkan Syndrome: a bioengieering approach (English version) http://www.idust.net/Docs/Nanoparticles01.htm

AM Gatti, Risk assessment of micro and nanoparticles and the human health, Chapter of Handbook of Nanostructured Biomaterials and their Applications, by American Scientific Publisher USA  – in press Dec 2004.

AM Gatti, Symposium Keynote Presentation “Risk Assessment of Nano-Particles and Nano-Technologies for Human Health. 7th World Biomaterials Congress- 2004, 748-749)

Sonia E. Miller, Esq., New York Law Journal Article on Converging Technologies (PDF) The Convergence of N: on Nanotechnology, Nanobiotechnology, and Nanomedicine December 2, 2003 Available at http://www.ctba.us/articles.asp

Safe exponential manufacturing, by Chris Phoenix and Eric Drexler http://www.iop.org/EJ/abstract/0957-4484/15/8/001/ — This paper explains that the so-called ‘gray goo problem’ is now less of a concern than are the implications of other forms of molecular manufacturing. The authors say “Nanotechnology-based fabrication can be thoroughly non-biological and inherently safe: such systems need have no ability to move about, use natural resources, or undergo incremental mutation. Moreover, self-replication is unnecessary: the development and use of highly productive systems of nanomachinery (nanofactories) need not involve the construction of autonomous self-replicating nanomachines. [However,] other concerns present greater problems. Since weapon systems will be both easier to build and more likely to draw investment, the potential for dangerous systems is best considered in the context of military competition and arms control.”

The Wise-Nano project, a collaborative website to study the facts and implications of advanced nanotechnology. It is a site for researchers worldwide to work together, helping to build an understanding of the technologies, their effects, and what to do about them.  http://wise-nano.org

Techonological Analysis: Industrial application of nanomaterials--chances and risks, Technologiezentrum, 2004

Chiu-Wing Lam, John T. James, Richard McCluskey, and Robert L. Hunter, Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days after Intratracheal Instillation, Toxicological Sciences, 2004, 77:126--134

D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Reynolds, and T. R. Webb, Comparative Pulmonary Toxicity Assessment of Single-Wall Carbon Nanotubes in Rats, Toxicological Sciences, 2004, 77:117-­125)

Kevin L. Dreher, Health and Environmental Impact of Nanotechnology: Toxicological Assessment of Manufactured Nanoparticles, Toxicological Sciences, 2004, 77:3-5

Joe Pappalardo, Military Ponders Future of Nanotech, National Defense, October 2004

Mihail C. Roco and WIlliam Sims (ed.), Societal Implications of Nanoscience and Nanotechnology, Bainbridge, Kluwer Academic Publishers 

Wolfgang Luther editor, Industrial Application of Nanomaterials - Chances and Risks, Technological Analysis (with support of the European Commission), Published by Future Technologies Division, Graf-Recke-Str. 84, Germany. http://www.zukuenftigetechnologien.de/11.pdf

Emerging Issues in Nanoparticle Aerosol Science and Technology, http://nano.gov:/html/res/NSFAerosolParteport.pdf
http://www.nano.gov/


What additional major ongoing or planned studies should be added to the list above to help understand the priorities in addressing these questions?


Additional Comments:


Thank you very much for your participation. The results will be sent to you in several months, and will be available later in the 2005 State of the Future.